期刊
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY
卷 22, 期 4, 页码 215-227出版社
KARGER
DOI: 10.1159/000341847
关键词
Quorum sensing; Bacteria; Autoinducers; Biotechnology
资金
- Ministry of Human Resource Development, Government of India
- Department of Defense (DoD) [W911NF-10-1-0146, W911NF-10-R-0006]
- Department of Biotechnology, Government of India
Quorum sensing (QS) represents an exceptional pattern of cell-to-cell communication in bacteria using self-synthesized signalling molecules known as autoinducers. Various features regulated by QS in bacteria include virulence, biofilm formation, sporulation, genetic competence and bioluminescence, among others. Other than the diverse signalling properties of autoinducers, there are non-signalling properties also associated with these signalling molecules which make them potential antimicrobial agents and metal chelators. Additionally, QS signal antagonism has also been shown to be a promising alternative for blocking pathogenic diseases. Besides, QS has impressive design features useful in tissue engineering and biosensor technology. Although many aspects of QS are well understood, several other features remain largely unknown, especially in biotechnology applications. This review focuses on the functional features and potential applications of QS signalling molecules in biotechnology. Copyright (C) 2012 S. Karger AG, Basel
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