期刊
JOURNAL OF MOLECULAR MEDICINE-JMM
卷 90, 期 5, 页码 471-480出版社
SPRINGER
DOI: 10.1007/s00109-012-0901-4
关键词
Evolutionary medicine; Comparative genomics; Primates; APOE; LPA
资金
- Max Planck Society
Within biomedicine, comparative genomics is crucial for interpreting human genetic variants and building proper animal models. As our closest relatives, primates are of particular relevance in this frame work. Here, I review principles and concrete examples of this approach. Since one can expect that generating the necessary genomic DNA sequences will not be the major limiting factor in the near future, I argue that in analogy to human biomedicine, comprehensive phenotyping of different primates will be a crucial next step to tap the full potential of comparative genomics. Especially the possibility to generate pluripotent stem cells from primates should allow extending the comparative approach to many medically relevant questions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据