期刊
JOURNAL OF MOLECULAR MEDICINE-JMM
卷 91, 期 1, 页码 15-23出版社
SPRINGER
DOI: 10.1007/s00109-012-0974-0
关键词
Osteoclast; Osteoblast; Wnt5a; Ror2; Bone resorption; Rheumatoid arthritis
资金
- Ministry of Education, Cultures, Sports, Science and Technology of Japan [23791668, 22390351, 23659972]
- Grants-in-Aid for Scientific Research [23791668] Funding Source: KAKEN
Osteoclasts, multinucleated giant cells, are responsible for bone resorption in physiological and pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclasts develop from the monocyte/macrophage lineage under the strict control of bone-forming osteoblasts. Osteoblast-lineage cells express two cytokines essential for osteoclast differentiation, colony-stimulating factor-1, and receptor activator of nuclear factor kappa B ligand (RANKL) and also express osteoprotegerin, a soluble decoy receptor for RANKL. The signaling molecule Wnt has been shown to be important for the differentiation of osteoblasts through beta-catenin-dependent canonical and beta-catenin-independent noncanonical pathways. Recent studies have established that Wnt-mediated signals are also crucial for bone resorption in both physiological and pathological conditions. In this review, we introduce recent advances in roles of Wnt signaling in bone formation and bone resorption.
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