期刊
JOURNAL OF MOLECULAR MEDICINE-JMM
卷 90, 期 5, 页码 587-595出版社
SPRINGER
DOI: 10.1007/s00109-011-0837-0
关键词
Colon cancer; DNA methylation; BRD4; Tumor suppressor gene
资金
- FIS [FI07/00380]
- IUOPA
- Spanish Ministry of Health [PI061267, PS09/02454]
- Spanish National Research Council [CSIC 200820I172]
- Community of Asturias [FICYT IB09-106]
- Obra Social Cajastur, Spain
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.
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