Ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) enhanced solubility and dissolution of indomethacin

The aim of the present investigation was to develop and evaluate ultra fine super self-nanoemulsifying drug delivery system (SNEDDS) of indomethacin (IND) to enhance its solubility as well as in vitro dissolution rate. Different SNEDDS formulations of IND were prepared by aqueous phase titration method. Prepared SNEDDS were subjected to different thermodynamic stability tests. Thermodynamically stable SNEDDS was selected for self-nanoemulsification efficiency test. Selected formulations were characterized in terms of droplet size distribution, viscosity and refractive index. Finally, selected SNEDDS (F1-F9) were subjected to in vitro dissolution/drug release studies. Droplet size and viscosity of formulation F1 was found to be lowest as compared to other formulations. The results of zeta potential indicated the formation of stable SNEDDS. In vitro drug release studies showed 98.4% release of IND from optimized formulation F1. The initial drug release profile of IND from optimized formulation F1 was found to be much faster than marketed IND capsule. The results of solubility studies showed around 4573 fold enhancement in solubility in F1 formulation compared to its aqueous solubility. These results indicated that developed SNEDDS could be successfully used for self-nanoemulsifying drug delivery of IND in order to enhance its solubility as well as in vitro dissolution rate. (C) 2013 Elsevier B.V. All rights reserved.