期刊
JOURNAL OF MOLECULAR HISTOLOGY
卷 44, 期 4, 页码 447-454出版社
SPRINGER
DOI: 10.1007/s10735-013-9487-6
关键词
NF-kappa B; Sjogren's syndrome; I kappa B alpha; Inflammation; Autoimmunity
类别
Diagnosis and therapeutic strategies in Sjogren's syndrome (SS) might greatly benefit of the present multidisciplinary approach to studying the molecular pathogenesis of the disease. A deregulated inflammatory response has been described in the SS. The research in the last years sheds light on the importance of the NF-kappa B pathway regulating the pro-inflammatory cytokine production and leukocyte recruitment. These are important contributors to the inflammatory response during the development of SS. In this study we examine the expression of the NF-kappa B inhibitory protein termed I kappa B alpha in salivary glands epithelial cells (SGEC) comparing it with SGEC from healthy controls, to test the hypothesis that an altered expression of I kappa B alpha occurs in SGEC from SS biopsies. Real-Time PCR, western blot and immunohistochemistry demonstrated that the expression level of I kappa B alpha was significantly lower in SS with respect to healthy controls leading to an increased NF-kappa B activity. Our results suggest that the analysis of I kappa B alpha expression at salivary gland epithelial cell level could be a potential new hallmark of SS progression and sustain a rationale to more deeply investigate the therapeutic potential of specific NF-kappa B inhibitors in SS.
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