期刊
JOURNAL OF MOLECULAR GRAPHICS & MODELLING
卷 27, 期 5, 页码 637-641出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jmgm.2008.10.004
关键词
Protein structure; Graphical representation; Virtual genetic code; Four-color map; Structure matrix S; Protein descriptor
类别
资金
- Ministry of Science, Education and Sports of the Republic of Croatia [098-0982929-2917, 065-0650446-0435, 037-0000000-2779, 177-0000000-0884]
- Ministry of Higher Education, Science and Technology of the Republic of Slovenia [P1-017, ARRS 1000-08-210382, P1-0294, JI-6062, LI-7230]
We put forward a novel compact 2-D graphical representation of proteins based on the concept of virtual genetic code and a four-color map. The novel graphical representation uniquely represents proteins and allows one to easily and quickly visually observe and inspect similarity/dissimilarity between them. It also leads to a novel protein descriptor, a 10-dimensional vector derived from a novel structure matrix S associated with the map. The introduced numerical characterization of proteins is not only useful for their comparative study, but also for cataloguing information on a single protein. The approach is illustrated with the A chain of human insulin and the A chain of human insulin analogue glargine. (C) 2008 Published by Elsevier Inc.
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