期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 51, 期 2, 页码 R51-R64出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-13-0079
关键词
endotoxemia; obesity; cardiovascular diseases
资金
- Portuguese Foundation for Science and Technology through the Cardiovascular RD Unit [PEst-C/SAU/UI0051/2011, PTDC/SAU-MET/116119/09]
- [SFRH/BD/52036/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/52036/2012, PEst-C/SAU/UI0051/2011] Funding Source: FCT
Obesity is associated with significantly increased cardiovascular (CV) risk and mortality. Several molecular mechanisms underlying this association have been implied, among which the intestinal barrier has gained a growing interest. In experimental models of obesity, significant alterations in the intestinal barrier lead to increased intestinal permeability, favoring translocation of microbiome-derived lipopolysaccharide to the bloodstream. This has been shown to result in a two-to threefold increase in its serum concentrations, a threshold named 'metabolic endotoxemia' (ME). ME may trigger toll-like receptor 4-mediated inflammatory activation, eliciting a chronic low-grade proinflammatory and pro-oxidative stress status, which may result in high CV risk and target-organ damage. In this review, we discuss the potential molecular implications of ME on several CV risk factors, such as obesity, insulin resistance, dyslipidemia, and oxidative stress, as well as its potential impact on the development of CV target-organ disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据