期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 42, 期 1-2, 页码 11-17出版社
BIOSCIENTIFICA LTD
DOI: 10.1677/JME-08-0122
关键词
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资金
- University of Leuven
- Fonds voor Weterschappelijk Onderzoek-Vlaanderen
Androgens play an important role in male reproductive development and function. These steroid hormones mediate their actions by binding to the androgen receptor (AR). Diseases such as androgen insensitivity syndrome, prostate cancer, Kennedy's disease, and infertility can be caused by mutations in the AR. To get a better insight into the molecular working mechanisms of the AR, several knockout and knock-in mouse models have been developed. These models are reviewed here and are compared with human diseases.
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