期刊
JOURNAL OF MOLECULAR DIAGNOSTICS
卷 11, 期 1, 页码 35-41出版社
AMER SOC INVESTIGATIVE PATHOLOGY, INC
DOI: 10.2353/jmoldx.2009.080082
关键词
-
类别
资金
- Czech Ministry of Health [IGA NR 9164-3]
- NATIONAL INSTITUTE OF NURSING RESEARCH [F31NR009164] Funding Source: NIH RePORTER
Hypertrophic cardiomyopathy is caused by mutations in the genes that encode sarcomeric proteins and is primarily characterized by unexplained left ventricular hypertrophy, impaired cardiac function, reduced exercise tolerance, and a relatively high incidence of sudden cardiac death, especially In die young. The extent of left ventricular hypertrophy is one of the major determinants of disease prognosis. Angiotensin II has trophic effects on the heart and plays an important role in the development of myocardial hypertrophy. Here in a double-blind, placebo-controlled, randomized study, we show that the long-term administration of the angiotensin H type 1. receptor antagonist candesartan in patients with hypertrophic cardiomyopathy was associated with the significant regression of left ventricular hypertrophy, improvement of left ventricular function, and exercise tolerance. The magnitude of the treatment effect was dependent on specific sarcomeric protein gene mutations that had the greatest responses on die carriers of beta-myosin heavy chain and cardiac myosin binding protein C gene mutations. These data indicate that modulating the role of angiotensin H in die development of hypertrophy is specific with respect to both die affected sarcomeric protein gene and the affected codon within that gene. Thus, angiotensin H type 1 receptor blockade has the potential to attenuate myocardial hypertrophy and may, therefore, provide a new treatment option to prevent sudden cardiac death in patients with hypertrophic cardiomyopathy. (J Mol Diagn 2009, 11:35-41; DOI: 10.2353/jmoldx.09.080082)
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据