期刊
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
卷 90, 期 -, 页码 98-106出版社
ELSEVIER
DOI: 10.1016/j.molcatb.2013.01.019
关键词
Green solvent; Eco-efficiency; Lipase; Selectivity; Surfactant
资金
- DSM Nutritional Products, Basel, Switzerland
The eco-efficient lipase catalyzed synthesis of sugar fatty acid ester surfactants from renewable commodities is a stimulating challenge in biotransformation. The biocatalytic investigations went from solvent-free and minimal ionic liquid use to bulk organic solvents, and binary solvents thereof. Disaccharide maltose was acylated with linoleic acid (C-18:2) on the primary O-6,6' hydroxyl functions. The ionic liquid [emim][MeSO3] and the potentially renewable acetone enabled best conversions. Binary solvents like acetone/DMF and [emim][MeSO3]/[bmpyr][PF6] tended to double conversions. The lipase selection is also crucial and the enzymes Pseudomonas cepacia and immobilized Candida antarctica allowed highest yields in a screening with 10 different lipases. Also other non-solvent parameters such as reaction time and molecular sieve content improved maltose transformation further up to 82%. Analysis by HPLC, ESI-MS, and NMR indicated the formation of mono-6 or 6'-O-linoleyl-alpha-D-maltose as a mixture of two regioisomers in a 1.4:1 ratio. From an applied point of view, the best solvent is acetone. Unlike ionic liquids and binary mixtures, it is easily removable from reaction mixtures. Moreover, acetone is to some degree a green solvent as it can be produced directly from renewable feedstock. (C) 2013 Elsevier B.V. All rights reserved.
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