期刊
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
卷 82, 期 -, 页码 96-101出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcatb.2012.06.009
关键词
Enzymatic kinetic resolution; 3-Phenyl-4-pentenoic acid; Femoxetine
资金
- project Biotransformations for pharmaceutical and cosmetics industry [POIG.01.03.01-00 -158/09-01]
- European Union
The studies on enzymatic kinetic resolution of 3-phenyl-4-pentenoic acid esters were performed. The obtained results demonstrated that the careful choice of biocatalyst and a reaction type are very important for successful enzymatic kinetic resolution. Kinetic resolution provides 3-phenyl-4-pentenoic acid (1) with good enantioselectivity upon esterification. That product was used as a substrate for formal synthesis of two biologically relevant compounds Femoxetine and LG 121071. (C) 2012 Elsevier B.V. All rights reserved.
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