期刊
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
卷 286, 期 1-2, 页码 41-46出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molcata.2008.01.035
关键词
nano-crystalline sulfated-zirconia; hydroxy derivatives of 4-methyl coumarin; microwave-assisted synthesis; Pechmann reaction
Nano-crystalline sulfated-zirconia solid acid catalyst has been studied for microwave-assisted solvent free synthesis of hydroxy derivatives of 4-methyl coumarin by Pechmann reaction. The catalyst showed good activity for activated m-hydroxy phenol substrates, viz., phloroglucinol and pyrrogallol with ethyl acetoacetate for the synthesis of 5,7-dihydroxy 4-methyl coumarin and 7,8-dihydroxy 4-methyl coumarin, respectively, showing significant yields ranging from 78 to 85% within 5-20 min at 130 degrees C. However, the less activated phenol and in-methyl phenol was observed to be inactive for the synthesis of 4-methyl coumarin and 4,7-dimethyl coumarin, respectively, under the studied experimental conditions. (C) 2008 Elsevier B.V. All rights reserved.
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