期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 425, 期 23, 页码 4756-4766出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2013.04.013
关键词
Cdk1; checkpoint; HR; NHEJ; resection
资金
- Associazione Italiana per la Ricerca sul Cancro [IG11407]
- Cofinanziamento MIUR/Universita di Milano-Bicocca
- Fondazione Italiana per la Ricerca sul Cancro
The eukaryotic cell cycle comprises a series of events, whose ordering and correct progression depends on the oscillating activity of cyclin-dependent kinases (Cdks), which safeguard timely duplication and segregation of the genome. Cell division is intimately connected to an evolutionarily conserved DNA damage response (DDR), which involves DNA repair pathways that reverse DNA lesions, as well as checkpoint pathways that inhibit cell cycle progression while repair occurs. There is increasing evidence that Cdks are involved in the DDR, in particular in DNA repair by homologous recombination and in activation of the checkpoint response. However, Cdks have to be carefully regulated, because even an excess of their activity can affect genome stability. In this review, we consider the physiological role of Cdks in the DDR. (C) 2013 Elsevier Ltd. All rights reserved.
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