期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 421, 期 4-5, 页码 427-440出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2012.01.006
关键词
amyloid; protein folding disease; oligomer; intermediate; structure
资金
- Deutsche Forschungsgemeinschaft [SFB 610]
- Bundesministerium fur Bildung und Forschung (ProNet-T3)
- country Sachsen-Anhalt (Exzellenznetzwerk Biowissenschaften)
Oligomeric intermediates are non-fibrillar polypeptide assemblies that occur during amyloid fibril formation and that are thought to underlie the aetiology of amyloid diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Focusing primarily on the oligomeric states formed from Alzheimer's disease beta-amyloid (A beta) peptide, this review will make references to other polypeptide systems, highlighting common principles or sequence-specific differences. The covered topics include the structural properties and polymorphism of oligomers, the biophysical mechanism of peptide self-assembly and its role for pathogenicity in amyloid disease. Oligomer-dependent toxicity mechanisms will be explained along with recently emerging possibilities of interference. (c) 2012 Elsevier Ltd. All rights reserved.
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