期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 410, 期 1, 页码 18-26出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2011.04.066
关键词
type II CAAX protease; APH-1; gamma-secretase; PrsW; DUF2324
资金
- National Institutes of Health [1R01GM094575-01, 2R01GM090328-06A1]
- Welch Foundation [I-1505]
- Department of Chemistry
- Institute for Genomic Biology at the University of Illinois at Urbana-Champaign
Intramembrane proteases are responsible for a number of regulated proteolysis events occurring within or near the plasma and intracellular membranes. Members of one large and diverse family of putative intramembrane metalloproteases are widely distributed in all domains of life, including the type H CAAX prenyl proteases and their prokaryotic homologs with putative bacteriocin-related functions. We used sensitive sequence similarity searches to expand this large CPBP (CAAX proteases and bacteriocin-processing enzymes) family to include more than 5800 members and infer its homologous relationships to several other protein families, including the PrsW proteases, the DUF2324 (DUF, domain of unknown function) family and the gamma-secretase subunit APH-1 proteins. They share four predicted core transmembrane segments and possess similar yet distinct sets of sequence motifs. Remote similarity between APH-1 and membrane proteases sheds light on APH-1's evolutionary origin and raises the possibility that APH-1 may possess proteolytic activity in the current or ancestral form of gamma-secretase. (C) 2011 Elsevier Ltd. All rights reserved.
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