期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 397, 期 4, 页码 865-877出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2010.02.005
关键词
cancer; superorganism; biofilm; disease; evolution
资金
- irsiCaixa [BFU2006/01066, PI07/0098]
- Centro Regional de Investigaciones Biomedicas [PI06/0584]
- Regional Government of Castilla La Mancha [PAI07-0011-3655]
- Centro Nacional de Microbiologia [SAP 2005/03833, SAF 2007-61036]
- Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss)
- Ministerio de Ciencia e Innovacion [BIO2007-60106, BIO2004-06114]
- Proyecto Excelencia Comunidad Autonoma de Andalucia [CVI-03050]
- FISS (CIBERehd)
- FIPSE [36549/06]
Experimental evidence that RNA virus populations consist of distributions of mutant genomes, termed quasispecies, was first published 31 years ago. This work provided the earliest experimental support for a theory to explain a system that replicated with limited fidelity and to understand the self-organization and adaptability of early life forms on Earth. High mutation rates and quasispecies dynamics of RNA viruses are intimately related to both viral disease and antiviral treatment strategies. Moreover, the quasispecies concept is being applied to other biological systems such as cancer research in which cellular mutant spectra can be also detected. This review addresses some of the unanswered questions regarding viral and theoretical quasispecies concepts as well as more practical aspects concerning resistance to antiviral treatments and pathogenesis. (C) 2010 Elsevier Ltd. All rights reserved.
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