期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 382, 期 5, 页码 1107-1112出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2008.07.081
关键词
chromatin; transcription; epigenetics; PRC1
资金
- European Molecular Biology Organization [ALTF 562-2002]
- MRC [MC_U105459896] Funding Source: UKRI
- Medical Research Council [MC_U105459896] Funding Source: researchfish
SCML2 (sex comb on midleg-like 2) is a constituent of the Polycomb repressive complex 1, a large multiprotein assembly required for the repression of developmental control genes. It contains two MBT (malignant brain tumor) repeats; the MBT is a protein module structurally similar to domains that bind to methylated histones. We have used NMR spectroscopy to examine the binding specificity of these repeats. Our data show that they preferentially bind histone peptides monomethylated at lysine residues with no apparent sequence specificity. The crystal structure of the complex between the protein and monomethyllysine reveals that the modified amino acid binds to an aromatic rich pocket at one end of the beta-barrel of the second repeat. (C) 2008 Elsevier Ltd. All rights reserved.
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