Redox regulation of cardiac hypertrophy

It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may be intricately linked with the process of hypertrophy wherein there is not only a significant increase in myocardial 02 consumption but also important alterations in metabolic processes and in the local generation of O-2-derived reactive species (ROS) that modulate and/or amplify cell signaling pathways. This article reviews our current knowledge of redox signaling pathways and their roles in cardiac hypertrophy. This article is part of a Special Issue entitled Redox Signalling in the Cardiovascular System. (c) 2014 The Authors. Published by Elsevier Ltd.