期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 73, 期 -, 页码 70-79出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2014.02.006
关键词
NADPH oxidase; Redox-regulation; Oxidative stress; Hydrogen peroxide; Thiol; Nitric oxide
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB815/TP1, SFB 834/TP2]
- Hugelschaffner-Stiftung
- Heinrich und Fritz-Riese-Stiftung
- DFG excellence cluster ECCPS
- Goethe University
The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled Redox Signalling in the Cardiovascular System. (c) 2014 Elsevier Ltd. All rights reserved:
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