期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 74, 期 -, 页码 98-102出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.yjmcc.2014.05.002
关键词
Chromatin; Transcription; Epigenetics; BET proteins; Cardiac hypertrophy; Heart failure
资金
- NIH [DK093821, HL116848, AG043822]
- Individual Biomedical Research Award from The Hartwell Foundation
Studies of transcriptional mechanisms in heart failure have focused heavily on roles of sequence-specific DNA-binding factors such as NFAT, MEF2 and GATA4. Recent findings have illuminated crucial functions for epigenetic regulators in the control of cardiac structural remodeling and mechanical dysfunction in response to pathological stress. Here, we review the current understanding of chromatin-dependent signal transduction in cardiac gene control, and highlight the potential for pharmacologic regulation of BET acetyl-lysine binding proteins as a means of treating heart failure. (C) 2014 Elsevier Ltd. All rights reserved.
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