期刊
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
卷 46, 期 3, 页码 318-331出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2008.10.024
关键词
Cardiac; Heart; Myocyte; pH(i); NHE; NBC; CHE; CBE; H+; OH-; HCO3-; Arrhythmia; Contraction; Cardioprotection
资金
- British Heart Foundation
- Royal Society and Medical Research Council
- National Institutes of Health [5R37HL042873]
- Nora Eccles Treadwell Foundation
- MRC [G0700698] Funding Source: UKRI
- British Heart Foundation [RG/08/016/26423] Funding Source: researchfish
- Medical Research Council [G0700698] Funding Source: researchfish
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R37HL042873] Funding Source: NIH RePORTER
Intracellular pH (pH(i)) is an important modulator of cardiac excitation and contraction, and a potent trigger of electrical arrhythmia. This review outlines the intracellular and membrane mechanisms that control pHi in the cardiac myocyte. We consider the kinetic regulation of sarcolemmal H+, OH- and HCO3- transporters by pH, and by receptor-coupled intracellular signalling systems. We also consider how activity of these pH(i) effector proteins is coordinated spatially in the myocardium by intracellular mobile buffer shuttles, gap junctional channels and carbonic anhydrase enzymes. Finally, we review the impact of pH(i) regulatory proteins on intracellular Ca2+ signalling, and their participation in clinical disorders such as myocardial ischaemia, maladaptive hypertrophy and heart failure. Such multiple effects emphasise the fundamental role that pHi regulation plays in the heart (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据