期刊
PEPTIDES
卷 72, 期 -, 页码 202-207出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2015.08.006
关键词
PACAP; PACAP receptors; Ischemia; Neuronal death; CRMP2; DNA microarray analysis
资金
- JSPS [23249079, 15K15670]
- Grants-in-Aid for Scientific Research [24592681, 23249079, 15H04394, 15K15670] Funding Source: KAKEN
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 27- or 38-amino acid neuropeptide, which belongs to the vasoactive intestinal polypeptide/glucagon/secretin family. PACAP and its three receptor subtypes are expressed in neural tissues, with PACAP known to exert pleiotropic effects on the nervous system. This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries. (C) 2015 Published by Elsevier Inc.
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