期刊
PEPTIDES
卷 63, 期 -, 页码 38-42出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2014.10.019
关键词
Cyclotides; Kalata; Wound infections; Phagocytosis; S. aureus
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Distrito Federal (FAPDF)
- Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT)
- Universidade Catolica de Brasilia (UCB)
- National Health and Medical Research Council [APP1028509]
- UQ Researcher Exchange Travel Grant
The main bacterium associated with skin infection is Staphylococcus aureus, occurring especially in infections acquired via surgical wounds, commonly leading to lethal hospital-acquired infections, emphasizing the importance of identifying new antimicrobial compounds. Among them, cyclotides have gained interest due to their high stability and multifunctional properties. Here, cycloviolacin 2 (CyO2) and kalata B2 (KB2) were evaluated to determinate their anti-staphylococcal activities using a subcutaneous infection model. Anti-staphylococcal activities of 50 mM for KB2 and 25 mM for CyO2 were detected with no cytotoxic activities against RAW 264.7 monocytes. In the in vivo assays, both cyclotides reduced bacterial load and CyO2 demonstrated an increase in the phagocytosis index, suggesting that the CyO2 in vivo anti-staphylococcal activity may be associated with phagocytic activity, additionally to direct anti-pathogenicactivity. (C) 2014 Elsevier Inc. All rights reserved.
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