期刊
PEDIATRICS INTERNATIONAL
卷 57, 期 4, 页码 582-585出版社
WILEY
DOI: 10.1111/ped.12587
关键词
acute otitis media; children; cohort study; effectiveness; pneumococcal conjugate vaccine
类别
资金
- Health and Labour Sciences Research Grants for Research on Emerging and Re-emerging Infectious Diseases from the Ministry of Health, Labor and Welfare in Japan [H23-SHINKO-IPPAN-017]
BackgroundSeven-valent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2009, and after that invasive pneumococcal disease has gradually decreased. There are few data, however, on the effectiveness of PCV7 against acute otitis media (AOM) in Japan. MethodsFrom 10 daycare centers in Sapporo, Japan, 614 parents participated in the survey. Each parent reported whether their child subject had received one or more doses of PCV7, and, if so, the exact dates of receiving PCV7 were verified by reviewing their maternal and child health handbooks marked by a pediatrician. AOM was diagnosed by otorhinolaryngologist or pediatrician. Cox's proportional hazard model was used for calculating the hazard ratio (HR) of AOM incidence reduced by PCV7 inoculation. ResultsInoculation of PCV7 significantly reduced the risk of AOM (crude HR, 0.63; 95%CI: 0.50-0.79). Adjusting for potentially confounding variables reduced the risk further (adjusted HR, 0.32; 95%CI: 0.23-0.44). On stratification by subject age on 30 April 2012, PCV7 was significantly associated with a reduced risk of AOM in both infants <3years old, and in children 3years. ConclusionPCV7 is effectiveness in reducing the risk of AOM both in infants <3years old, and in young children 3years in Japan.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据