期刊
PEDIATRICS INTERNATIONAL
卷 57, 期 1, 页码 169-171出版社
WILEY-BLACKWELL
DOI: 10.1111/ped.12414
关键词
bevacizumab; glioblastoma; irinotecan; posterior reversible encephalopathy syndrome
类别
A 5-year-old boy with glioblastoma relapsed soon after postoperative irradiation in combination with temozolomide. Second-line chemotherapy was also ineffective; therefore, the bevacizumab and irinotecan were given after a third gross-total resection of the tumor. Treatment was interrupted for 1 month due to development of posterior reversible encephalopathy syndrome, but was re-initiated at a lower dose of bevacizumab with prolonged intervals between treatments. The patient was alive and disease free 2 years after initial diagnosis. Bevacizumab and irinotecan are a promising regimen for pediatric cases of recurrent glioblastoma after gross-total resection, although the optimal treatment schedule must be determined on a patient-by-patient basis.
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