期刊
JOURNAL OF MICROSCOPY
卷 251, 期 3, 页码 250-260出版社
WILEY
DOI: 10.1111/jmi.12064
关键词
Extracellular matrix (ECM); invasion; MT1-MMP
类别
资金
- NIH [CA88308, CA71699]
During development, wound repair and disease-related processes, such as cancer, normal, or neoplastic cell types traffic through the extracellularmatrix (ECM), the complex composite of collagens, elastin, glycoproteins, proteoglycans, and glycosaminoglycans that dictate tissue architecture. Current evidence suggests that tissue-invasive processes may proceed by protease-dependent or protease-independent strategies whose selection is not only governed by the characteristics of the motile cell population, but also by the structural properties of the intervening ECM. Herein, we review the mechanisms by which ECM dimensionality, elasticity, crosslinking, and pore size impact patterns of cell invasion. This summary should prove useful when designing new experimental approaches for interrogating invasion programs as well as identifying potential cellular targets for next-generation therapeutics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据