期刊
JOURNAL OF MICROSCOPY
卷 232, 期 3, 页码 463-475出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2818.2008.02141.x
关键词
3d reconstruction; biopolymer network; collagen gel; confocal microscopy; image processing
类别
资金
- NIH [R01 CA085139-01A2]
- Institute for Mathematics and its Applications
- Swiss National Science Foundation
- NSF
The geometric structure of a biopolymer network impacts its mechanical and biological properties. In this paper, we develop an algorithm for extracting the network architecture of three-dimensional (3d) fluorescently labeled collagen gels, building on the initial work of Wu et al., (2003). Using artificially generated images, the network extraction algorithm is then validated for its ability to reconstruct the correct bulk properties of the network, including fiber length, persistence length, cross-link density, and shear modulus.
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