期刊
JOURNAL OF MICROENCAPSULATION
卷 30, 期 7, 页码 674-680出版社
INFORMA HEALTHCARE
DOI: 10.3109/02652048.2013.774447
关键词
Shirasu porous glass membrane; spray drying; nanoparticle; flurbiprofen; polyvinylpyrrolidone
资金
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2012R1A2A2A01045658]
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [A092018]
- National Research Foundation of Korea [2012R1A2A2A01045658] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A unique flurbiprofen-loaded nanoemulsion was listed earlier using a Shirasu porous glass (SPG) membrane emulsification technique, which gave constant emulsion droplets with a thin size distribution. In this study, a flurbiprofen-loaded nanoemulsion was developed further into a solid form using polyvinylpyrrolidone (PVP) as a carrier by a spray-drying technique. The flurbiprofen-loaded nanoparticles with a weight ratio of flurbiprofen/PVP/surfactant mixture of 1/8/2 were connected with about 130 000-fold enhanced drug solubility and had a mean size of about 70 nm. In these nanoparticles, flurbiprofen was found in an altered amorphous state. Additionally, the nanoparticles gave significantly shorter T-max, and greater AUC and C-max compared to the commercially available product. Specially, the AUC of the drug from the nanoparticles was about 10-fold greater compared to the commercially available product. Therefore, these flurbiprofen-loaded nanoparticles can be convenient for distributing a poorly water-soluble flurbiprofen with improved bioavailability using uniform nano-sized particles.
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