期刊
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
卷 47, 期 1, 页码 75-78出版社
ELSEVIER TAIWAN
DOI: 10.1016/j.jmii.2012.07.008
关键词
BD GeneOhm RT-PCR; C. Diff Quik Check Complete; Clostridium difficile; ProGastro Cd RT-PCR
The analytical performance and cost-effectiveness of the Wampole Toxin A/B EIA, the C. Diff. Quik Chek Complete (CdQCC) (a combined glutamate dehydrogenase antigen/toxin enzyme immunoassay), two RT-PCR assays (Progastro Cd and BD GeneOhm) and a modified two-step algorithm using the CdQCC reflexed to RT-PCR for indeterminate results were compared. The sensitivity of the Wampole Toxin A/B EIA, CdQCC (GDH antigen), BD GeneOhm and Progastro Cd RT-PCR were 85.4%, 95.8%, 100% and 93.8%, respectively. The algorithm provided rapid results for 86% of specimens and the remaining indeterminate results were resolved by RT-PCR, offering the best balance of sensitivity and cost savings per test (algorithm similar to US$13.50/test versus upfront RT-PCR similar to US$26.00/test). Copyright (C) 2012, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.
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