期刊
PEDIATRIC TRANSPLANTATION
卷 19, 期 5, 页码 499-503出版社
WILEY-BLACKWELL
DOI: 10.1111/petr.12531
关键词
renal transplantation; chronic rejection; autoantibody
资金
- Washington University Institute of Clinical and Translational Sciences grant from the National Center for Advancing Translational Sciences [UL1 TR000448]
- Mentored Training Program in Clinical Investigation through the same grant
- BJC foundation
Chronic rejection is the leading cause of graft loss following pediatric kidney transplantation. Our group and others have demonstrated an association between the development of Abs to self-antigens and chronic rejection following adult lung and heart transplantation. The goal of this study was to determine whether Abs to kidney-associated self-antigens develop following pediatric renal transplantation. We investigated post-transplant development of Abs to kidney-associated self-antigens angiotensin II receptor type I, Fn, and collagen IV in a pediatric cohort. Using ELISA, we measured Abs to kidney-associated self-antigens in serum. Our cohort included 29 subjects with samples collected pretransplant and for 12months post-transplant. No samples had Abs to kidney-associated self-antigen pretransplant. In contrast, 50% (10/20) of subjects developed Abs to one or more kidney-associated self-antigen post-transplantation. The median time to antibody appearance and duration of persistence were 103 and 61days, respectively. Development of Abs did not correlate with graft function. Half of subjects developed Abs to kidney-associated self-antigens angiotensin II receptor type I, Fn, or collagen IV in the first year after kidney transplantationa higher rate of early antibody development than expected. In this small study, Abs did not correlate with worse clinical outcomes.
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