期刊
JOURNAL OF MEMBRANE SCIENCE
卷 364, 期 1-2, 页码 194-202出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.memsci.2010.08.017
关键词
Dopamine; Polyethylene porous membranes; Self-polymerization; Heparin immobilization
资金
- National Nature Science Foundation of China [50803054]
- China Postdoctoral Science Foundation [200902633]
- National Basic Research Program of China [2009CB623402]
- Engineering Research Center of Membrane and Water Treatment Technology, Ministry of Education, Zhejiang university [KYJD09011]
Based on the self-polymerization and strong adhesion characteristic of dopamine in wet conditions, the hydrophobic polyethylene (PE) porous membranes were surface-modified via simply immersing them into dopamine aqueous solution for 24 h. Subsequently, heparin was immobilized covalently onto the resultant membrane by the coupling between heparin and reactive polydopamine layer. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS) were utilized to determine the chemical compositions of membrane surface, which confirmed the successful introduction of polydopamine and immobilization of heparin molecules. Scanning electronic microscopy (SEM) and atomic force microscopy (AFM) were employed to investigate the changes in surface morphologies after surface modification. The data of water contact angle measurements indicated that the hydrophilicity of PE membranes was remarkably improved after polydopamine coating and heparin immobilization. The results of in vitro hemocompatibility test proved that surface heparinization significantly suppressed the adhesion of platelet and enhanced the anticoagulation ability of PE membranes. This work offered a convenient approach to improve the permeability and biocompatibility of inert PE porous membranes for their biomedical and blood-contacting applications. (C) 2010 Elsevier B.V. All rights reserved.
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