期刊
JOURNAL OF MEMBRANE SCIENCE
卷 326, 期 1, 页码 58-63出版社
ELSEVIER
DOI: 10.1016/j.memsci.2008.09.039
关键词
Hemofiltration; Artificial kidney; Nanotechnology; MEMS; Silicon
资金
- National Institute of Biomedical Imaging and Bioengineering, NIH [1K08 EB003468, 1 R01 EB008049-01]
- U.S. Army Medical Research and Materiel Command, DoD [W81XWH-05-2-0010]
- Directorate For Engineering
- Div Of Engineering Education and Centers [0755263] Funding Source: National Science Foundation
Silicon micromachining provides the precise control of nanoscale features that can be fundamentally enabling for miniaturized, implantable medical devices. Concerns have been raised regarding blood biocompatibility of silicon-based materials and their application to hemodialysis and hemofiltration. A high-performance ultrathin hemofiltration membrane with monodisperse slit-shaped pores was fabricated using a sacrificial oxide technique and then surface-modified with poly(ethylene glycol) (PEG). Fluid and macromolecular transport matched model predictions well. Protein adsorption, fouling, and thrombosis were significantly inhibited by the PEG. The membrane retained hydraulic permeability and molecular selectivity during a 90-h hemofiltration experiment with anticoagulated bovine whole blood. This is the first report of successful prolonged hemofiltration with a silicon nanopore membrane. The results demonstrate feasibility of renal replacement devices based on these membranes and materials. (C) 2008 Elsevier B.V. All rights reserved.
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