期刊
JOURNAL OF MEMBRANE SCIENCE
卷 321, 期 2, 页码 324-330出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.memsci.2008.05.016
关键词
superparamagnetic microcapsules; thermo-responsive membranes; controlled-release; drug carriers; site targeting drug delivery systems
A novel dual stimuli-responsive microcapsule with a superparamagnetic porous membrane and linear-grafted poly(N-isopropylacrylamide) (PNIPAM) gates in the membrane pores is successfully prepared and characterized. Oleic acid (OA)-modified Fe3O4 nanoparticles are embedded into the polyamide microcapsule membrane during interfacial polymerization process, and then plasma-induced grafting polymerization is used to graft PNIPAM into the pores of microcapsule membranes. The prepared microcapsule membranes exhibit time-independent superparamagnetic property with good magnetic-responsive ability, and satisfactory thermo-responsive controlled-release property due to the thermo-responsive swollen/shrunken property of PNIPAM gates grafted on the inner pore surface of the microcapsule membranes. (c) 2008 Elsevier B.V. All rights reserved.
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