期刊
JOURNAL OF MEMBRANE BIOLOGY
卷 246, 期 5, 页码 365-373出版社
SPRINGER
DOI: 10.1007/s00232-013-9540-0
关键词
Resveratrol; Mitochondrial permeability transition; Membrane fluidity; Lipid peroxidation; Respiration
资金
- National Natural Science Foundation of China [21077081, 21273065, 21203035, 20921062]
- National Science Foundation for Distinguished Young Scholars of China [21225313]
Resveratrol (RSV), a natural polyphenolic antioxidant, has been considered an anticarcinogenic agent as it triggers tumor cell apoptosis through activation of the mitochondrial pathway. In our study, the effects of RSV on mitochondria, especially on the mitochondrial permeability transition (MPT) process, were investigated by multiple methods. We found that RSV induced a collapse of membrane potential and matrix swelling related to MPT. We further demonstrated that Ca2+ was necessary for this RSV-induced MPT opening. In addition, RSV induced the inner membrane permeabilization to H+ and K+, the depression of respiration and changes in membrane fluidity. The results suggested that RSV-induced MPT was accompanied by mitochondrial dysfunction. But the prohibition on lipid peroxidation and different effects of low- and high-dose RSV on membrane fluidity and respiration showed that the interaction of RSV and the mitochondria could not be the result of a single simple mechanism.
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