期刊
JOURNAL OF MEDICINAL FOOD
卷 17, 期 6, 页码 670-677出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2013.0007
关键词
antioxidant activity; CCl4; hepatoprotection; naringenin
The present study evaluated the antioxidant and hepatoprotective effects of the flavonoid naringenin (NGN) and its beta-cyclodextrin formulation at a dose of 50 mg/kg b.w. The assessment was done by the investigation of serum-enzymatic and liver antioxidant activity, histopathological and ultrastructural changes in male Swiss mice, which were subjected to acute experimental intoxication with CCl4. Formulated and free flavonoid were orally given to mice for 7 days and then were intraperitoneally injected with 1.0 mL/kg CCl4 on the 8th day. After 24 h of CCl4 administration, an increase in the levels of transaminases aspartate aminotransferase and alanine aminotransferase activities and malondialdehyde concentration occurred and a significant decrease in superoxide dismutase, catalase glutathione-peroxidase activities, and glutathione levels was detected as well. These were accompanied by extended centrilobular necrosis, steatosis, fibrosis, and an altered ultrastructure of hepatocytes. Pretreatment with formulated or free flavonoid retained the biochemical markers to control values. Histopathological and electron-microscopic examination confirmed the biochemical results. In conclusion, both NGN and NGN/beta-cyclodextrin complex showed antioxidant and hepatoprotective effects against injuries induced by CCl4.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据