期刊
JOURNAL OF MEDICINAL FOOD
卷 17, 期 4, 页码 496-504出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2013.2941
关键词
atopic dermatitis; Cnidii Fructus; NC/Nga atopic dermatitis murine model; Spirodelae Herba; SSC201; Stemonae Radix
资金
- National Research Foundation of Korea Grant - Korean Government [NRF-2010-013-E00033]
- Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [HI12C1954]
- Korea Science and Engineering Foundation (KOSEF) - Korea Government (MEST) [2010-0012505]
- RIC program of the MKE (Ministry of Knowledge Economy) of Daejeon University
- National Research Foundation of Korea [2010-0012505] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Atopic dermatitis (AD) is a chronic inflammatory skin disease, which requires safe and effective treatment. In this study, we evaluated the effects of SSC201, a herbal formulation consisting of Stemonae Radix, Spirodelae Herba, and Cnidii Fructus, on the development of AD induced by 2,4-dinitrochlorobenzene in the NC/Nga murine model. Oral administration of SSC201 significantly reduced the severity of dermatitis and the tendency of mice to scratch their lesions. SSC201 significantly reduced the thickening of the epidermis/dermis and the infiltration of T cells, eosinophils, and mast cells into the dermis. These results were supported by findings of reduced numbers of CD4(+), CCR3(+), and CD117(+)Fc epsilon RI alpha(+) cells in the skin. Furthermore, SSC201 significantly decreased the number of CD4(+), CD8(+), and CD3(+)CD69(+) T cells in lymph nodes. SSC201 not only decreased the plasma levels of immunoglobulin E (IgE) and the numbers of IgE-producing B cells (B220(+)CD23(+)), but also reduced the number of eosinophils and the levels of eotaxin as well as concentrations of thymus and activation-regulated chemokine in the periphery. Splenic levels of Th2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, were reduced, whereas the levels of IL-12, a Th1 cytokine, were increased. Taken together, our data suggest that SSC201 may be an effective therapeutic agent for the treatment of AD.
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