期刊
JOURNAL OF MEDICINAL FOOD
卷 16, 期 11, 页码 977-983出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2012.2739
关键词
Alzheimer's disease; amyloid beta peptide; oxidative stress; PC12 cells
资金
- National Research Foundation of Korea (NRF)
- Korea government (Ministry of Science, ICT & Future Planning) [NRF-2010-0005094]
In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on the pheochromocytoma cell line (PC12) was investigated. The active component of the sweet potato extract was purified and determined to be 2,4-di-tert-butylphenol. The antioxidant capacity of 2,4-di-tert-butylphenol was measured by using 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine the effects of 2,4-di-tert-butylphenol on amyloid-beta peptide (A(1-42))-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Administration of 2,4-di-tert-butylphenol increased alternation behavior in mice injected with A(1-42). These results suggest that sweet potato extract could be protective against A-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 2,4-di-tert-butylphenol.
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