期刊
JOURNAL OF MEDICINAL FOOD
卷 15, 期 11, 页码 955-958出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2011.0340
关键词
antiproliferative assay; cancer cell lines; plant extracts; Mentha rotundifolia; Mentha spicata
资金
- National Council of Scientific and Technology Development of Brazil (CNPq)
This study assessed the antiproliferative effect in vitro of the flower hexane extract obtained from Mentha spicata associated with Mentha rotundifolia against the human breast adenocarcinoma (MCF-7), human mouth epidermal carcinoma (KB), and mouse embryonic fibroblast (NIH 3T3) cell lines, using sulforhodamine B (SRB) assay. A cell density of 2 x 10(4)/well was seeded in 96-well plates, and samples at different concentrations ranging from 10 to 500mg/mL were tested. The optical density was determined in an ELISA multiplate reader (Thermo Plate TP-Reader). Results demonstrated that the hexane extract presented antiproliferative activity against both the tumor cell lines KB and MCF-7, presenting a GI(50) (MCF-7 = 13.09 mg/mL), TGI (KB = 37.76mg/mL), and IL50 (KB = 291.07 mg/mL). Also, the hexane extract presented antiproliferative activity toward NIH 3T3 cells GI(50) (183.65 mg/mL), TGI (280.54mg/mL), and IL50 (384.59mg/mL). The results indicate that the flower hexane extract obtained from M. spicata associated with M. rotundifolia presents an antineoplastic activity against KB and MCF-7, although an antiproliferative effect at a high concentration of the extract was observed toward NIH 3T3.
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