期刊
JOURNAL OF MEDICINAL FOOD
卷 14, 期 10, 页码 1118-1126出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2010.0220
关键词
antidiabetic and anti-inflammatory effects; cytokines; Passiflora edulis; pectin
Flour made from Passiflora edulis fruit peel has been used in Brazil to treat diabetes. This study evaluated the effects of pectin from P. edulis on rats with alloxan-induced diabetes, on myeloperoxidase release from human neutrophils, and on carrageenan-induced paw edema. In the experiments on carrageenan-induced paw edema, paws were dissected for hematoxylin eosin staining and immunohistochemistry determinations of tumor necrosis factor-alpha and inducible nitric oxide synthase. Male Wistar rats were divided into the following groups: diabetic controls and diabetic treated with pectin daily for 5 days (0.5-25 mg/kg orally). Glibenclamide and metformin were used as reference drugs. Forty-eight hours after alloxan administration, blood measures were determined (before treatment) and again 5 days later (after treatment). Pectin decreased blood glucose and triglyceride levels in diabetic rats. Pectin also decreased edema volume and release of myeloperoxidase (0.1-100 mu g/mL). It also significantly decreased neutrophil infiltration and partially decreased immunostaining for tumor necrosis factor-cc and inducible nitric oxide synthase. In conclusion, these data indicated that pectin, a bioactive compound present in P. edulis, has potential as a useful alternative treatment for type 2 diabetes. Its anti-inflammatory properties are probably involved in its antidiabetic action.
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