期刊
PEDIATRIC RESEARCH
卷 79, 期 1, 页码 3-12出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2015.179
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资金
- National Institute of Neurological Disorders and Stroke [5U01NS040069-05, 2R01NS040069-06A2]
- National Eye Institute [1-R01-EY021820-01]
- National Institute of Child Health and Human Development [5P30HD018655-28]
Children of obese mothers are at increased risk of developmental adversities. Maternal obesity is linked to an inflammatory in utero environment, which, in turn, is associated with neurodevelopmental impairments in the offspring. This is an integrated mechanism review of animal and human literature related to the hypothesis that maternal obesity causes maternal and fetal inflammation, and that this inflammation adversely affects the neurodevelopment of children. We propose integrative models in which several aspects of inflammation are considered along the causative pathway linking maternal obesity with neurodevelopmental limitations.
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