期刊
JOURNAL OF MEDICINAL FOOD
卷 14, 期 11, 页码 1412-1418出版社
MARY ANN LIEBERT INC
DOI: 10.1089/jmf.2010.0257
关键词
antioxidant; cytotoxicity; DNA damage; methyl-3-O-methyl gallate; Peltiphyllum peltatum; prooxidant; reactive oxygen species
资金
- HEFCE
Methyl-3-O-methyl gallate (M3MG) is a rare natural product with close structural similarity to gallic acid. In the present report, the isolation of M3MG from Peltiphyllum peltatum leaves and its comparative antioxidant, prooxidant, and cytotoxicity to neuronal SH-SY5Y cells are discussed. When tested in concentrations up to 1 mM, M3MG consistently showed antioxidant activity without prooxidant effect both in cell and cell-free assay models. In contrast to M3MG, gallic acid showed a copper-dependent prooxidant effect that resulted in DNA damage, increased the level of intracellular reactive oxygen species, and induced cytotoxicity in neuronal cells. The identification of M3MG in P. peltatum leaves is furtherz evidence of the great antioxidant potential and nutritional value of the plant.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据