期刊
JOURNAL OF MEDICINAL FOOD
卷 13, 期 2, 页码 286-290出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2009.0071
关键词
cancer cells; cell cycle analysis; cytotoxic activity; diterpenes; Greek flora; manool; propolis
资金
- General Secretariat of Research and Technology of Greece [2001]
- Korres Natural Products, S. A
The butanolic extract and the isolated chemical constituents, mainly diterpenes and flavonoids, from Greek propolis have been tested for their cytostatic activities against human malignant and normal cell strains. The extract and the diterpenes were found to be the most active against HT-29 human colon adenocarcinoma cells, without affecting normal human cells. Manool, a diterpene isolated for the first time from Greek propolis, was the most active compound, arresting the cancer cells at the G(2)/M phase of the cell cycle.
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