期刊
JOURNAL OF MEDICINAL FOOD
卷 11, 期 4, 页码 615-622出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2007.0588
关键词
gene; glucan; immunology; mushrooms; yeast
资金
- Division of Cancer Treatment, Drug Synthesis and Chemistry Branch, National Cancer Institute (Bethesda, MD)
Glucans have a long history as nonspecific biological modulators. We compared the effects of three different glucans on immune reactions. Using two different administrations (intraperitoneal and oral) and two different animal models, we showed that yeast-derived Betamune(TM) (Biorigin, Sao Paulo, Brazil) caused significant stimulation of phagocytic activity as well as potentiation of synthesis and release of interleukin (IL)-1, IL-2, IL-4, IL-6, IL-8, IL-13, and tumor necrosis factor alpha. In addition, Betamune inhibited growth of tumor cells in vivo and affected expression of several important genes in breast cancer cells. Compared to adult mice, young animals showed different sensitivity to glucan action.
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