期刊
JOURNAL OF MEDICINAL FOOD
卷 11, 期 3, 页码 513-517出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2007.0551
关键词
exopolysaccharide; hypoglycemic effect; Lentinus strigosus
资金
- Eskisehir Osmangazi University Research Foundation [200619016]
- Scientific Research and Application Centre (FBAM)
- Department of Biology, Eskisehir Osmangazi University
This study reports the hypoglycemic effects of the crude exopolysaccharide (EPS) produced from submerged mycelial culture of Lentinus strigosus (Schwein.) Fr. (Family Polyporaceae) in streptozotocin (STZ)-induced diabetic rats. In a dose-dependent study, diabetic rats were treated with EPS at doses of 50-150 mg/kg of body weight for 7 days. Serum glucose and plasma insulin levels were measured in normal, STZ-induced diabetic, and EPS-treated diabetic rats. Following oral administration of FPS dosages for 7 days, the serum glucose levels in the STZ-induced diabetic rats were reduced up to 21.1% at the dose of 150 mg/kg of body weight. The results revealed that orally administered L. strigosus EPS, at the dose of 150 mg/kg, exhibited a considerable hypoglycemic effect in STZ-induced diabetic rats. Plasma insulin levels of STZ-induced diabetic rats decreased as compared to control group rats (P <.05). Although insulin levels slightly increased in the EPS-treated groups the increase was not statistically significant. The hypoglycemic potential of the EPS was further supported by histological observations of pancreatic islets of Langerhans.
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