期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 61, 期 20, 页码 9386-9392出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.8b01137
关键词
-
资金
- ICSN
3,3'-Spirocyclopentene oxindoles structurally related to Wang's spiropyrrolidine oxindoles have been highlighted as a new class of antiproliferative agents against cancer cell lines with wild-type p53 status (IC50 up to 0.96 mu M on SJSA-1 and 2.9 mu M in HCT116 p53-wt). Inhibition of the MDM2-p53 interactions has been demonstrated through in vitro HTRF assays (IC50 up to 3.1 nM), while Western blot analysis showed activation of p53 selectively in HCT116 cancer cell lines with wild-type p53.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据