期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 58, 期 1, 页码 72-95出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm501212r
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资金
- Institutional Strategy of the University of Tubingen (Deutsche Forschungsgemeinschaft) [ZUK 63]
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.
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