期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 4, 页码 1609-1615出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm401905m
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资金
- Network of Antimicrobial Resistance in Staphylococcus aureus (NARSA) program under NIAID/NIH [HHSN272200700055C]
- Showalter Research Trust [205994]
- Purdue Research Foundation (PRF)
Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 mu g/mL.
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