期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 24, 页码 10455-10463出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm501501a
关键词
-
资金
- MINECO (Spain) [SAF2012-33304]
- Universidad Camilo Jose Cela (Madrid, Spain) [MULTIMOL 2013-20]
- MINECO
- COST action [CM1103]
- Ministry of Education and Science of the Republic of Serbia [CM1207, 172033]
- Spanish Ministry of Economy and Competitiveness [SAF2012-31035]
- CSIC [PIE-201280E074]
- Fundacion de Investigacion Medica Mutua Madrilena Automovilistica [AP103952012]
On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据