期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 57, 期 17, 页码 7459-7464出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm501083y
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资金
- Australian National Health and Medical Research Council [570933, 1031686]
omega-3-17,18-Epoxyeicosapentaenoic acid decreases cell proliferation and activates apoptosis, whereas its regioisomers stimulate growth. We evaluated synthetic omega-3 epoxides of saturated fatty acids as antiproliferative and pro-apoptotic agents in MDA-MB-231 breast cancer cells. The epoxides, but not their urea, amide, or carbamate isosteres, impaired ATP production, enhanced caspase-3 activity, and activated c-jun-N-terminal-kinase signaling, leading to cyclin D1 down-regulation and cell cycle arrest in G(1)-phase. Fatty acid omega-3 monoepoxides may represent a novel class of antitumor agents.
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